Team

PI: Nitish Thakor, Professor

PI: Nitish Thakor, Professor

PI: Nitish Thakor, Professor

Romergryko Geocadin

PI: Nitish Thakor, Professor

PI: Nitish Thakor, Professor

Johns Hopkins Medicine

Sujatha Kannan

PI: Nitish Thakor, Professor

Sujatha Kannan

Johns Hopkins Medicine

Postdocs and Associates

Qihong Wang

David Sherman

David Sherman

Research Associate

David Sherman

David Sherman

David Sherman

Research Associate.

Hiren Modi

David Sherman

Hiren Modi

Postdoctoral Fellow

Alumni

Arvind Pathak

J. Muthuswamy

Arvind Pathak

Johns Hopkins University

Amir Manbachi

J. Muthuswamy

Arvind Pathak

 Johns Hopkins University 

J. Muthuswamy

J. Muthuswamy

J. Muthuswamy

Postdoctoral Fellow

Shanbao Tong

Shanbao Tong

J. Muthuswamy

PhD Student and Postdoctoral Fellow

Xiaofeng Jia

Shanbao Tong

Xiaofeng Jia

Postdoctoral Fellow

Angelo All

Shanbao Tong

Xiaofeng Jia

 Postdoctoral Fellow 

Hyunchool Shin

Matthew Koening

Matthew Koening

Postdoctoral Fellow

Matthew Koening

Matthew Koening

Matthew Koening

 Post doctoral Fellow, Neurology with R. Geocadin 

Wei Xiong

Matthew Koening

Wei Xiong

 Post doctoral Fellow, Neurology with R. Geocadin

Dan Wu

Xiaoxu Kang

Wei Xiong

Masters Student

Xiaoxu Kang

Xiaoxu Kang

Xiaoxu Kang

Masters Student

Publications

Reviews

 Thakor NV, Shin HC, Tong S, Geocadin RG, “Quantitative EEG assessment,” IEEE Eng Med Biol Mag, 25(4):20-5, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16898654 

Original Papers

  

Qihong Wang (Research Associate) Miao P., Li M., Li N., Rege A., Yisheng Z., Thakor N., Tong S., “Detecting cerebral arteries and veins: from large to small,” J. Innovative Optical Health Sci.,Vol. 03 (01), pp. 61-67, 2010.http://dx.doi.org/10.1142/s1793545810000794 .


Wu W., Guo X, Jiang D., Sun J., Qiu Y., Zhu Y., Thakor N. V., Tong S., “Influence of hypoxic-preconditioning on autonomic regulation following global ischemic brain injury in rats,” Neurosci. Letters, Vol. 480 (3), pp. 191-195, 2010.http://dx.doi.org/10.1016/j.neulet.2010.06.029.


Miao P., Li M., Li N., Rege A., Yisheng Z., Thakor N., Tong S., “Detecting cerebral arteries and veins: from large to small,” J. Innovative Optical Health Sci.,Vol. 03 (01), pp. 61-67, 2010.http://dx.doi.org/10.1142/s1793545810000794 .


Wu W., Guo X, Jiang D., Sun J., Qiu Y., Zhu Y., Thakor N. V., Tong S., “Influence of hypoxic-preconditioning on autonomic regulation following global ischemic brain injury in rats,” Neurosci. Letters, Vol. 480 (3), pp. 191-195, 2010.http://dx.doi.org/10.1016/j.neulet.2010.06.029.


Geocadin RG, Muthuswamy J, Sherman DL, Thakor NV, Hanley DF,      “Early electrophysiological and histologic changes after global cerebral      ischemia in rats,” Mov Disord, 15 Suppl 1:14-21, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10755267 


Geocadin RG, Ghodadra R, Kimura T, Lei H, Sherman DL, Hanley DF, Thakor NV, “A novel quantitative EEG injury measure of global cerebral      ischemia,” Clin Neurophysiol, 111(10):1779-87, 2000. http://www.ncbi.nlm.nih.gov/pubmed/11018492 


Luft AR, Kaelin-Lang A, Hauser TK, Cohen LG, Thakor NV, Hanley DF, “Transcranial magnetic stimulation in the rat,” Exp Brain Res,      140(1):112-21, 2001. 


Muthuswamy J, Kimura T, Ding MC, Geocadin R, Hanley DF, Thakor NV,  “Vulnerability of the thalamic somatosensory pathway after prolonged global hypoxic-ischemic injury,” Neuroscience, 115(3):917-29, 2002. http://www.ncbi.nlm.nih.gov/pubmed/12435429 


Sherman DL, Atit MK, Geocadin RG, Venkatesha SV, Hanley DF,  Natarajan AL, Thakor NV, “Diagnostic instrumentation for neurological injury,” IEEE Instrum. Measurement Mag., 5:28-35, 2002.


Boardman A, Schlindwein FS, Thakor NV,  Kimura T, Geocadin RG, “Detection of asphyxia using heart rate      variability,” Med Biol Eng Comput, 40(6):618-24, 2002.

 

Bezerianos A, Tong S, Thakor N, “Time-dependent entropy estimation  of EEG rhythm changes following brain ischemia,” Ann Biomed Eng, 31(2):221-32, 2003. http://www.ncbi.nlm.nih.gov/pubmed/12627829 


Tong S, Bezerianos A, Malhotra A, Zhu Y, Thakor N, “Parameterized entropy analysis of EEG following hypoxic-ischemic brain injury,” Phys Lett A, 314(5-6):354-361, 2003.


Moraru L, Cimponeriu L, Tong S, Thakor N, Bezerianos A, “Characterization of heart rate variability changes following asphyxia in rats,” Methods Inf Med, 43(1):118-21, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15026851

 

Moraru L, Tong S, Malhotra A, Geocadin R, Thakor N, Bezerianos A, “Investigation of the effects of ischemic preconditioning on the HRV      response to transient global ischemia using linear and nonlinear methods,”      Med Eng Phys, 27(6):465-73, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15990063 


Al-Nashash HA, Thakor NV, “Monitoring of global cerebral ischemia using wavelet entropy rate of change,” IEEE Trans Biomed Eng, 52(12):2119-22, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16370057 


Geocadin RG, Malhotra AD, Tong S, Seth A, Moriwaki G, Hanley DF, Thakor NV, “Effect of acute hypoxic preconditioning on qEEG and functional recovery after cardiac arrest in rats,” Brain Res, 1064(1-2):146-54, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16289119 


Geocadin RG, Malhotra AD, Tong S, Seth A, Moriwaki G, Hanley DF, Thakor NV, “Effect of acute hypoxic preconditioning on qEEG and functional recovery after cardiac arrest in rats,” Brain Res,, 1064(1-2):146-54, 2005. http://www.ncbi.nlm.nih.gov/pubmed/16289119 


Shin HC, Tong S, Yamashita S, Jia X, Geocadin RG, Thakor NV, “Quantitative EEG and effect of hypothermia on brain recovery after cardiac arrest,” IEEE Trans Biomed Eng, 53(6):1016-23, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16761828 


Thakor NV, Shin HC, Tong S, Geocadin RG, “Quantitative EEG assessment,” IEEE Eng Med Biol Mag, 25(4):20-5, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16898654 


Jia X, Koenig MA, Shin HC, Zhen G, Yamashita S, Thakor NV, Geocadin RG, “Quantitative EEG and neurological recovery with therapeutic hypothermia after asphyxial cardiac arrest in rats,” Brain Res,      1111(1):166-75, 2006. http://www.ncbi.nlm.nih.gov/pubmed/16919609 


Tong S, Jiang D, Wang Z, Zhu Y,  Geocadin RG, Thakor NV, “Long range correlations in the heart rate      variability following the injury of cardiac arrest,” Physica A,380:250-258, 2007.


Murari K, Li N, Rege A, Jia X, All A, Thakor NV,  Contrast-enhanced imaging of cerebral vasculature with laser speckle,” Appl Opt, 46(22):5340-6, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17676149 


Schreckinger M, Geocadin RG, Savonenko A, Yamashita S, Melnikova  T, Thakor NV, Hanley DF, “Long-lasting cognitive injury in rats with      apparent full gross neurological recovery after short-term cardiac      arrest,” Resuscitation, 75(1):105-13, 2007. http://www.ncbi.nlm.nih.gov/pubmed/17475391 


Jia X, Koenig MA, Shin HC, Zhen G, Pardo CA, Hanley DF, Thakor NV, Geocadin RG, “Improving neurological outcomes post-cardiac arrest in a rat model: Immediate hypothermia and quantitative EEG monitoring,” Resuscitation, 76(3):431-42, 2008. http://www.ncbi.nlm.nih.gov/pubmed/17936492


Jia X, Koenig MA, Nickl R, Zhen G, Thakor NV, Geocadin RG, “Early electrophysiologic markers predict      functional outcome associated with temperature manipulation after cardiac  arrest in rats,” Crit Care Med, 36(6):1909-16, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18496359 


Jia X, Koenig MA, Venkatraman A, Thakor NV, Geocadin RG, “Post-cardiac arrest temperature manipulation alters early EEG bursting in rats,” Resuscitation, 78(3):367-73, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18597914 


Shin HC, Jia X, Nickl R, Geocadin RG, Thakor NV, “A subband-based information measure of EEG during brain injury and  recovery after cardiac arrest,” IEEE Trans Biomed Eng, 55(8):1985-90, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18632361 


Kang X, Geocadin R, Thakor NV, Maybhate A, “ Multiscale entropy analysis of EEG for assessment of      post-cardiac-arrest neurological recovery under hypothermia in rats,” IEEE Trans. Biomed. Eng., Vol. 56(4), pp. 1023-1031, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19174339


Koenig M. A., Jia X, Kang X, Velasquez A, Thakor NV, and Geocadin RG, “Intraventricular Orexin-A improves arousal and early EEG entropy in rats after cardiac arrest,” Brain Res, Vol. 1255, pp.153-161, 2009 . http://www.ncbi.nlm.nih.gov/pubmed/19174339 


Xiong W, Koenig M, Madhok J, Jia X, Puttgen HA, Thakor NV, and Geocadin RG, "Evolution of somatosensory evoked potentials after cardiac arrest induced hypoxic-ischemic injury," Resuscitation, Vol. 81(7):893-897, 2010. Epub 2010 Apr 24. http://www.ncbi.nlm.nih.gov/pubmed/20418008


Madhok J, Maybhate A, Xiong W, Koenig MA, Geocadin, RG, Jia X, Thakor NV, "Quantitative assessment of somatosensory evoked      potentials after cardiac arrest in rats: prognostication of functional outcomes" Critical Care Med., Vol. 38(8), pp. 1709-1717, 2010


Miao P., Li M., Li N., Rege A., Yisheng Z., Thakor N., Tong S., “Detecting cerebral arteries and veins: from large to small,” J. Innovative Optical Health Sci.,Vol. 03 (01), pp. 61-67, 2010.http://dx.doi.org/10.1142/s1793545810000794 .


Wu W., Guo X, Jiang D., Sun J., Qiu Y., Zhu Y., Thakor N. V., Tong S., “Influence of hypoxic-preconditioning on autonomic regulation following global ischemic brain injury in rats,” Neurosci. Letters, Vol. 480 (3), pp. 191-195, 2010.http://dx.doi.org/10.1016/j.neulet.2010.06.029.


Wu D, Anastassios B, Xiong W, Madhok J, Jia X, Thakor NV, "Study of the origin of short- and long-latency SSEP      during recovery from brain ischemia in a rat model, " Neurosci Lett, Vol. 13, 2010 Sep 13. http://www.ncbi.nlm.nih.gov/pubmed/20816917.


Sherman DL,  Zhang N, Garg S, Thakor NV, Mirksi MA, White MA, Hinich MJ,“Detection of nonlinear interactions of EEG Alpha waves in the brain by a new coherence measure and its application to epilepsy,” Int. J. Neural Systems, Vol. 21, No. 2, pp. 115-126, 2011. DOI: 10.1142/S0129065711002754


Ma Y, Hu Y, Valentin N, Geocadin RG, Thakor NV, Jia X, Time jitter of somatosensory evoked potentials in recovery from hypoxic–ischemic brain injury,”  J. Neurosci. Methods, Vol. 201, pp. 355– 360, 2011.


 Wu D, Xiong W, Jia X., Geocadin R., Thakor N. V. “Short-and long-latency somatosensory neuronal responses reveal selective brain injury and effect of hypothermia in global hypoxic ischemia” Am Physiol Soc, Vol. 107(4), pp 1164-1171,15 Feb 2012.


Madhok J, Wu D, Xiong W, Geocadin RG, Jia X, “Hypothermia amplifies somatosensory evoked potentials in uninjured rats,” J. Neurosurg. Anesthesiol. Vol. 24, no. 3, pp. 197-202, 2012.


Modi H. R., Wang Q., Sahithi      G.D., Sherman D., Greenwald E., Savonenko A. V., Geocadin R. G., Thakor N.      V., “Intranasal post-cardiac arrest treatment with orexin-A facilitates      arousal from coma and ameliorates neuroinflammation,” PloS One 12 (9), e0182707, 2017.


Cha K. M., Thakor N. V., Shin H. C.,      “Novel early EEG measures predicting brain      recovery after cardiac arrest,” Entropy 19 (9), 466, 2017.


Sherman D., Wang      Q., Modi H., and Thakor N. V., “Quantitative EEG demonstrates recovery and      arousal by intra-nasal orexin after cardiac arrest” (submitted, 2019).